Description

Bms 986188 is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) research compound, identified by CAS No. 1776115-10-6. This compound is critical for advancing pharmaceutical research, particularly in the development of novel antiviral therapies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and contract research organizations (CROs) engaged in virology, medicinal chemistry, and preclinical drug discovery.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the discovery and optimization of new antiviral drugs.
• Biochemical Assays: Used as a reference standard or inhibitor in enzymatic and cellular assays to study HIV reverse transcriptase activity and mechanism of action.
• Medicinal Chemistry Studies: Employed in structure-activity relationship (SAR) studies to design and synthesize more potent and selective NNRTI analogs.
• Preclinical Development: Utilized in in vitro and in vivo models to evaluate pharmacokinetics, efficacy, and toxicity profiles of candidate drug molecules.
• Academic Research: Supports fundamental virology and antiviral resistance research in university and institutional laboratories.

Basic Information

Product Name	Bms 986188
CAS No.	1776115-10-6
Molecular Formula	C₂₀H₂₀F₂N₆O₂
Molecular Weight	414.41 g/mol
Synonyms	BMS-986188; 1-[(2S)-1-Hydroxy-4-methyl-1-oxopentan-2-yl]-5-(2,6-difluorobenzyl)-6-(2,2,2-trifluoroethoxy)-1H-pyrimidine-2,4-dione; (2S)-2-[[5-[(2,6-Difluorophenyl)methyl]-6-(2,2,2-trifluoroethoxy)-2,4-dioxo-1-pyrimidinyl]oxy]-4-methylpentanoic acid; BMS986188; NNRTI research compound BMS-986188
EINECS	Contact for details

Quality Control

Every batch of Bms 986188 is manufactured under strict quality management systems. We provide comprehensive analytical data to support research integrity, including identity confirmation, purity assessment, and impurity profiling via advanced chromatographic and spectroscopic techniques. A Certificate of Analysis (COA) detailing batch-specific results is supplied with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.