Description

1,1,1-Trifluoro-n-[(11Bs)-8,9,10,11,12,13,14,15-Octahydro-4-Oxido-2,6-Diphenyl-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Yl]Methanesulfonamide is a sophisticated chiral organophosphorus compound designed for advanced chemical synthesis. This high-value intermediate is critical for enabling asymmetric catalysis and the development of novel active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers specializing in complex, stereoselective transformations.

Application

• Chiral Ligand/Precursor: Serves as a key building block or precursor for the synthesis of novel chiral phosphine-oxazoline (PHOX) or related ligand families used in asymmetric hydrogenation and cross-coupling reactions.
• Pharmaceutical Intermediate: Employed in the research and development of new therapeutic agents, particularly where the introduction of a trifluoromethylsulfonamide (triflylamide) group and precise stereochemistry is required for bioactivity.
• Catalyst Development: Used in academic and industrial research to create new metal-organic catalysts for enantioselective synthesis, improving yield and selectivity in the production of chiral molecules.
• Material Science Research: Potential application in the development of advanced organic materials where its unique fused polycyclic and phosphorus-containing structure can impart specific electronic or self-assembly properties.
• Process Chemistry Optimization: Utilized by fine chemical manufacturers to develop and scale up efficient, proprietary synthetic routes for high-value compounds.

Basic Information

Product Name	1,1,1-Trifluoro-n-[(11Bs)-8,9,10,11,12,13,14,15-Octahydro-4-Oxido-2,6-Diphenyl-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Yl]Methanesulfonamide
CAS No.	1773513-29-3
Molecular Formula	C33H27F3NO4PS
Molecular Weight	621.60 g/mol
Synonyms	(11bS)-8,9,10,11,12,13,14,15-Octahydro-4-oxido-2,6-diphenyl-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl 1,1,1-trifluoromethanesulfonamide; N-[(11bS)-8,9,10,11,12,13,14,15-Octahydro-4-oxido-2,6-diphenyl-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl]-1,1,1-trifluoromethanesulfonamide; Trifluoromethanesulfonamide, N-[(11bS)-8,9,10,11,12,13,14,15-octahydro-4-oxido-2,6-diphenyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl]-; Chiral Phosphorus Triflylamide Derivative; (S)-H8-BINOL-Derived Triflyl Phosphoramidate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be sensitive to moisture; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.