Description

tert-Butyl4-(3-Amino-6-((1S,3S,4S)-4-((tert-Butyldimethylsilyl)Oxy)-3-Fluorocyclohexyl)Pyrazin-2-Yl)-2-Fluorobenzoate is a sophisticated, high-purity fluorinated pyrazine derivative designed for advanced pharmaceutical research and development. This compound serves as a critical building block (advanced intermediate) in the synthesis of complex drug candidates, particularly those targeting challenging disease pathways. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require precisely controlled stereochemistry and functional groups to develop next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel active pharmaceutical ingredients (APIs), especially for oncology, CNS, and antiviral drug discovery programs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique fluorocyclohexyl and protected hydroxyl motifs.
• Process Chemistry & Scale-up: Serves as a defined intermediate for route scouting and optimization during the transition from laboratory to pilot and commercial-scale manufacturing.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential utility as a component in the linker or ligand portions of bifunctional degrader molecules.
• Chemical Biology Probe Synthesis: Enables the creation of tool compounds for investigating biological targets and pathways in cellular models.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring high-complexity fluorinated intermediates.

Basic Information

Product Name	tert-Butyl4-(3-Amino-6-((1S,3S,4S)-4-((tert-Butyldimethylsilyl)Oxy)-3-Fluorocyclohexyl)Pyrazin-2-Yl)-2-Fluorobenzoate
CAS No.	1715032-87-3
Molecular Formula	C27H40F2N4O3Si
Molecular Weight	534.73 g/mol
Synonyms	2-Fluorobenzoic acid, 4-[3-amino-6-[(1S,3S,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-fluorocyclohexyl]-2-pyrazinyl]-, 1,1-dimethylethyl ester; (1S,3S,4S)-4-((tert-Butyldimethylsilyl)oxy)-3-fluorocyclohexyl pyrazine intermediate; tert-Butyl 4-(3-amino-6-((1S,3S,4S)-4-((tert-butyldimethylsilyl)oxy)-3-fluorocyclohexyl)pyrazin-2-yl)-2-fluorobenzoate; TBDMS-protected fluorocyclohexyl pyrazine benzoate; CAS 1715032-87-3; Fluorinated Pyrazine Intermediate 1715032-87-3; Stereo-defined Fluorinated Building Block.
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols in facilities that adhere to cGMP guidelines for advanced intermediates. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with each shipment. Our quality system ensures traceability and consistency, meeting the stringent requirements of pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. The compound is moisture-sensitive; allow the sealed container to equilibrate to room temperature before opening to prevent condensation. Keep away from strong bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.