Description

3-Bromo-5-((1S,3S,4S)-4-((tert-Butyldimethylsilyl)Oxy)-3-Fluorocyclohexyl)Pyrazin-2-Amine is a high-purity, advanced pharmaceutical intermediate designed for complex synthesis pathways. This compound matters because it provides a critical, stereochemically defined building block for the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and antiviral research. It is essential for medicinal chemists and process development scientists in pharmaceutical R&D and contract manufacturing organizations (CMOs) who require reliable, high-quality intermediates for their drug discovery and development pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting protein kinases and other critical enzymes.
• Antiviral Drug Development: Serves as a precursor in the research and production of novel antiviral agents, leveraging its halogenated pyrazine core.
• Oncology Therapeutics: Used in the construction of targeted cancer therapies, where its specific stereochemistry and functional groups are crucial for biological activity.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or probe in studying protein-ligand interactions and biological pathways.
• Process Chemistry & Scale-Up: Supports route scouting, optimization, and cGMP manufacturing for clinical trial material and commercial API production.
• Custom Synthesis & Contract Research: A valuable starting material for specialty chemical suppliers and CROs offering bespoke synthesis services to the biopharma industry.

Basic Information

Product Name	3-Bromo-5-((1S,3S,4S)-4-((tert-Butyldimethylsilyl)Oxy)-3-Fluorocyclohexyl)Pyrazin-2-Amine
CAS No.	1715032-86-2
Molecular Formula	C16H27BrFN3OSi
Molecular Weight	404.40 g/mol
Synonyms	3-Bromo-5-[(1S,3S,4S)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-fluorocyclohexyl]-2-pyrazinamine; (1S,3S,4S)-4-((tert-Butyldimethylsilyl)oxy)-3-fluorocyclohexyl)-3-bromopyrazin-2-amine; TBS-protected fluorocyclohexyl bromopyrazinamine; CAS 1715032-86-2; 2-Amino-3-bromo-5-((1S,3S,4S)-4-((tert-butyldimethylsilyl)oxy)-3-fluorocyclohexyl)pyrazine
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-((1S,3S,4S)-4-((tert-Butyldimethylsilyl)Oxy)-3-Fluorocyclohexyl)Pyrazin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for advanced pharmaceutical applications. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.