Description

5-((1S,3S,4S)-4-((tert-Butyldimethylsilyl)Oxy)-3-Fluorocyclohexyl)Pyrazin-2-Amine is a high-value, stereochemically defined advanced pharmaceutical intermediate (API intermediate) featuring a fluorinated cyclohexyl scaffold protected by a tert-butyldimethylsilyl (TBDMS) group. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases. Its precise stereochemistry and functional groups make it an essential building block for pharmaceutical companies and contract research organizations (CROs) engaged in cutting-edge small molecule drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to develop new therapeutic agents.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• CNS Drug Discovery: The fluorinated cyclohexyl moiety is valuable for creating molecules with enhanced blood-brain barrier (BBB) penetration for neurological targets.
• Kinase Inhibitor Synthesis: The pyrazin-2-amine core is a privileged structure found in many kinase inhibitors for oncology applications.
• Process Chemistry & Scale-Up: Supports route scouting and optimization from milligram to kilogram scale for clinical trial material (CTM) production.

Basic Information

Product Name	5-((1S,3S,4S)-4-((tert-Butyldimethylsilyl)Oxy)-3-Fluorocyclohexyl)Pyrazin-2-Amine
CAS No.	1715032-85-1
Molecular Formula	C16H28FN3OSi
Molecular Weight	325.50 g/mol
Synonyms	(1S,3S,4S)-4-[(tert-Butyldimethylsilyl)oxy]-3-fluoro-1-(5-aminopyrazin-2-yl)cyclohexane; 5-[(1S,3S,4S)-4-[(tert-Butyldimethylsilyl)oxy]-3-fluorocyclohexyl]pyrazin-2-amine; 5-((1S,3S,4S)-4-((Tert-Butyldimethylsilyl)oxy)-3-fluorocyclohexyl)pyrazin-2-amine; TBDMS-protected fluorocyclohexylpyrazinamine; (1S,3S,4S)-3-Fluoro-4-((tert-butyldimethylsilyl)oxy)-1-(5-aminopyrazin-2-yl)cyclohexane
EINECS	Contact for details

Quality Control

Every batch of 5-((1S,3S,4S)-4-((tert-Butyldimethylsilyl)Oxy)-3-Fluorocyclohexyl)Pyrazin-2-Amine is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our products are supported by a detailed Certificate of Analysis (COA) that includes data from HPLC, NMR (1H, 13C, 19F), LC-MS, and chiral purity analysis. We adhere to cGMP guidelines for advanced intermediates and can provide material suitable for use in pre-clinical and clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.