Description

tert-Butyl 4-Amino-4-[3-(Trifluoromethyl)Phenyl]Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core substituted with a trifluoromethylphenyl group. This compound is of significant commercial importance due to its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for neurological disorders and cancer treatments.
• API Synthesis: Serves as a crucial precursor in multi-step synthetic routes for constructing complex molecules with potential biological activity.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization processes due to its versatile piperidine scaffold and trifluoromethyl group.
• Chemical Biology Probes: Can be utilized in the development of chemical probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by fine chemical manufacturers for the contract synthesis of specialized, non-commercial compounds for client research programs.

Basic Information

Product Name	tert-Butyl 4-Amino-4-[3-(Trifluoromethyl)Phenyl]Piperidine-1-Carboxylate
CAS No.	1713160-77-0
Molecular Formula	C17H23F3N2O2
Molecular Weight	344.37 g/mol
Synonyms	1-Boc-4-Amino-4-(3-trifluoromethylphenyl)piperidine; 4-Amino-4-(3-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-amino-4-(3-(trifluoromethyl)phenyl)piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-amino-4-(3-trifluoromethylphenyl)piperidine; 4-(3-Trifluoromethylphenyl)-4-aminopiperidine-1-carboxylic acid tert-butyl ester; 4-Amino-4-(α,α,α-trifluoro-m-tolyl)piperidine-1-carboxylic acid tert-butyl ester; BOC-4-Amino-4-(3-trifluoromethylphenyl)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Amino-4-[3-(Trifluoromethyl)Phenyl]Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring material traceability and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, containers should be kept tightly sealed to exclude moisture. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.