Description

Parecoxib CAS NO 1709956-95-5 is a potent and selective cyclooxygenase-2 (COX-2) inhibitor, developed as a prodrug of valdecoxib for injectable administration. This compound is of significant commercial interest for its targeted mechanism of action, which offers a valuable therapeutic profile for managing acute pain and inflammation. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development of parenteral analgesic and anti-inflammatory formulations.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in injectable analgesic formulations.
• Postoperative Pain Management: A key component in drugs developed for the short-term management of acute postoperative pain.
• Anti-inflammatory Research: Used as a reference standard and tool compound in pharmacological research focused on COX-2 inhibition pathways.
• Prodrug Development Studies: Serves as a model compound in pharmaceutical science research exploring prodrug design and hydrolysis kinetics.
• Analgesic Formulation Development: Utilized in R&D for developing new non-opioid, parenteral pain relief solutions.

Basic Information

Product Name	Parecoxib
CAS No.	1709956-95-5
Molecular Formula	C19H18N2O4S
Molecular Weight	370.42 g/mol
Synonyms	Parecoxib Sodium; SC 69124A; Valdecoxib Prodrug; Dynastat (Brand Name); 3-(4-Methoxyphenyl)-4-(4-methylsulfonylphenyl)-5H-furan-2-one; N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide (related); COX-2 Inhibitor Prodrug
EINECS	Contact for details

Quality Control

Our Parecoxib is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical intermediates and API synthesis. Quality is assured through comprehensive analytical testing including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for every batch to confirm compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.