Description

4-[2-(Trifluoromethyl)Phenyl]Piperidin-4-Amine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethylphenyl-piperidine amine structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting the central nervous system. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its privileged piperidine scaffold and fluorine substitution.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in API manufacturing.
• Preclinical Development: Employed in the production of compounds for pharmacological screening and early-stage toxicology studies.
• Academic Research: Used in university and institutional labs for investigating new synthetic pathways and biological mechanisms.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial chemical entities for client-specific projects.

Basic Information

Product Name	4-[2-(Trifluoromethyl)Phenyl]Piperidin-4-Amine Dihydrochloride
CAS No.	1707361-50-9
Molecular Formula	C12H16Cl2F3N2
Molecular Weight	307.17 g/mol
Synonyms	4-Amino-4-[2-(trifluoromethyl)phenyl]piperidine dihydrochloride; 4-(2-(Trifluoromethyl)phenyl)piperidin-4-amine dihydrochloride; 4-Piperidinamine, 4-[2-(trifluoromethyl)phenyl]-, dihydrochloride; 1,1-Dimethylethyl 4-[2-(trifluoromethyl)phenyl]-4-piperidinecarboxylate (precursor); 4-(α,α,α-Trifluoro-o-tolyl)-4-piperidinamine dihydrochloride
EINECS	Contact for details

Quality Control

Our 4-[2-(Trifluoromethyl)Phenyl]Piperidin-4-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Assay (Titration)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.