Description

tert-Butyl (3R,4S)-3-Amino-4-(((Benzyloxy)Carbonyl)Amino)Piperidine-1-Carboxylate is a high-purity, stereochemically defined chiral piperidine derivative that serves as a critical building block in modern organic synthesis. Its value lies in its dual-protected amino functionality, which provides orthogonal deprotection strategies essential for constructing complex molecular architectures. This advanced pharmaceutical intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for therapeutic areas requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Peptidomimetic Research: Used in the construction of peptidomimetic scaffolds where the piperidine core mimics proteinogenic amino acids.
• Medicinal Chemistry: Employed in lead optimization and structure-activity relationship (SAR) studies to introduce specific stereochemistry and functional groups.
• Chemical Biology: Serves as a precursor for labeled compounds or probes used in target identification and validation.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in catalytic asymmetric transformations.
• Custom Synthesis: A foundational component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	tert-Butyl (3R,4S)-3-Amino-4-(((Benzyloxy)Carbonyl)Amino)Piperidine-1-Carboxylate
CAS No.	1707290-21-8
Molecular Formula	C18H27N3O4
Molecular Weight	349.43 g/mol
Synonyms	1-Boc-3-amino-4-[(benzyloxycarbonyl)amino]piperidine (3R,4S)-; (3R,4S)-1-(tert-Butoxycarbonyl)-4-[(benzyloxycarbonyl)amino]-3-aminopiperidine; tert-Butyl N-[(3R,4S)-3-amino-4-{[(benzyloxy)carbonyl]amino}piperidin-1-yl]formate; (3R,4S)-1-Boc-3-Amino-4-Cbz-Amino-Piperidine; (3R,4S)-3-Amino-4-(N-Cbz-amino)-1-Boc-piperidine; 1-Boc-3-NH2-4-NHCbz-piperidine (3R,4S)-; Boc-3-Amino-4-CbzNH-Piperidine (3R,4S)-; Chiral Boc-Cbz Protected Diaminopiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl (3R,4S)-3-Amino-4-(((Benzyloxy)Carbonyl)Amino)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and identity, to ensure compliance with the highest standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.