Description

tert-Butyl 4-(4-Iodobenzyl)-Piperizine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core with a protected amine and a halogenated benzyl group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas such as central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protecting Group Chemistry: The tert-butyloxycarbonyl (Boc) group allows for selective protection and deprotection of the piperazine nitrogen during multi-step syntheses.
• Cross-Coupling Reactions: The iodine substituent on the benzyl ring makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce diverse aryl and alkynyl groups.
• Library Synthesis: Employed in the parallel and combinatorial synthesis of compound libraries for high-throughput screening.
• Chemical Biology Probes: Useful for creating labeled or tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	tert-Butyl 4-(4-Iodobenzyl)-Piperizine-1-Carboxylate
CAS No.	1706437-45-7
Molecular Formula	C16H23IN2O2
Molecular Weight	402.27 g/mol
Synonyms	1-Boc-4-(4-iodobenzyl)piperazine; tert-Butyl 4-[(4-iodophenyl)methyl]piperazine-1-carboxylate; 4-(4-Iodobenzyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl 4-[(4-iodophenyl)methyl]-1-piperazinecarboxylate; 4-(4-Iodobenzyl)piperazine-1-carboxylic acid tert-butyl ester; Boc-4-(4-iodobenzyl)piperazine; 1706437-45-7
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Iodobenzyl)-Piperizine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (NMR, IR), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.