Description

(4-(4-(tert-Butoxycarbonyl)Piperazine-1-Carbonyl)-3-Chlorophenyl)Boronic Acid is a sophisticated boronic acid derivative featuring a protected piperazine and a chlorophenyl scaffold. This compound matters as a key synthetic intermediate in modern organic and medicinal chemistry, enabling the construction of complex molecules through versatile cross-coupling reactions. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of new active ingredients, particularly in the synthesis of protease inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of drug candidates, especially those targeting proteases and kinases.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for the formation of carbon-carbon bonds in complex molecule assembly.
• Agrochemical Research: Used in the development of novel herbicides and fungicides with enhanced efficacy.
• Chemical Biology Probes: Enables the creation of tagged molecules for studying biological pathways and target engagement.
• Material Science: Potential precursor for functionalized polymers and advanced organic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and reference standards.

Basic Information

Product Name	(4-(4-(tert-Butoxycarbonyl)Piperazine-1-Carbonyl)-3-Chlorophenyl)Boronic Acid
CAS No.	1704097-56-2
Molecular Formula	C16H22BClN2O4
Molecular Weight	352.62 g/mol
Synonyms	[4-[4-[(2-Methylpropan-2-yl)oxycarbonyl]piperazine-1-carbonyl]-3-chlorophenyl]boronic acid; Boc-Piperazine-3-Chlorophenylboronic Acid; 3-Chloro-4-(4-Boc-piperazine-1-carbonyl)benzeneboronic acid; 1-Boc-4-[4-borono-2-chlorobenzoyl]piperazine; (3-Chloro-4-(4-(tert-butoxycarbonyl)piperazine-1-carbonyl)phenyl)boronic acid; Boc-Pip-Cph-B(OH)2 (abbrev.); 1704097-56-2; N-Boc-4-(4-borono-2-chlorobenzoyl)piperazine
EINECS	Contact for details

Quality Control

Our (4-(4-(tert-Butoxycarbonyl)Piperazine-1-Carbonyl)-3-Chlorophenyl)Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.