Description

Cotadutide Acetate is a synthetic peptide analog with significant therapeutic potential. This compound is a dual agonist of the glucagon-like peptide-1 (GLP-1) and glucagon receptors, making it a key candidate for metabolic research and pharmaceutical development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel treatments for metabolic disorders such as type 2 diabetes, obesity, and non-alcoholic steatohepatitis (NASH).

Application

• Pharmaceutical Research & Development: Primary use in preclinical and clinical studies for metabolic diseases.
• Drug Discovery Programs: Serves as a reference standard and active pharmaceutical ingredient (API) in the development of next-generation GLP-1/glucagon receptor agonists.
• Metabolic Disorder Studies: Investigation of mechanisms related to glucose homeostasis, weight regulation, and liver fat metabolism.
• Biochemical Assay Development: Used as a critical reagent in establishing in vitro and in vivo screening assays.
• Academic Research: Fundamental research on peptide hormone signaling pathways in university and institutional labs.
• GMP Manufacturing: Sourcing of high-purity material for cGMP-grade production of clinical trial materials.

Basic Information

Product Name	Cotadutide Acetate
CAS No.	1686108-82-6
Molecular Formula	C225H347N61O67S
Molecular Weight	5093.5 g/mol
Synonyms	MEDI0382 Acetate; GLP-1/Glucagon Dual Agonist (Cotadutide); GUB-D-003 Acetate; LY3305677 (related); GLP-1/Glucagon Co-agonist Peptide; Cotadutide (Acetate salt); (8-37)hGLP-1-Glu-Glu-Glu-Ala-Tyr-Leu-Asp-Ser-Lys-Asp-Leu-Lys-Glu-Met-Ser-Glu-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-Lys-Arg-Asn-Arg-Asn-Asn-Ile-Ala-NH2 Acetate
EINECS	Contact for details

Quality Control

Our Cotadutide Acetate is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical research. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and related substances. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to support regulatory filings (e.g., FDA, EMA).

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (IC)	3.0 - 8.0%
Peptide Content (AAA)	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.