Description

(Asp28)-Exenatide CAS NO 1678417-24-7 is a synthetic, high-purity peptide analog of exendin-4, engineered with a specific aspartic acid substitution at position 28. This modification is critical for enhancing the compound's stability and biological activity profile, making it a valuable intermediate in advanced pharmaceutical research and development. It is primarily utilized by biopharmaceutical companies and research institutions focused on developing next-generation therapeutics for metabolic disorders.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel glucagon-like peptide-1 (GLP-1) receptor agonists for the treatment of type 2 diabetes.
• Research & Development: Used in preclinical and clinical research to study the structure-activity relationships (SAR) of incretin mimetics.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development, validation, and quality control in peptide manufacturing.
• Drug Discovery: Employed in high-throughput screening and bioassay development to identify and optimize new therapeutic candidates targeting metabolic pathways.
• Bioconjugation Studies: Utilized in research exploring peptide-drug conjugates or other modified biologics with enhanced pharmacokinetic properties.

Basic Information

Product Name	(Asp28)-Exenatide
CAS No.	1678417-24-7
Molecular Formula	C184H282N50O60S
Molecular Weight	4186.6 g/mol
Synonyms	Exenatide (Asp28); [Asp28]Exendin-4; (28-Aspartic acid)Exendin-4; LADA Exenatide analog; GLP-1 receptor agonist analog; Synthetic exendin-4 derivative; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 (Asp28 variant)
EINECS	Contact for details

Quality Control

Our (Asp28)-Exenatide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity, mass spectrometry (MS) for confirmation, and tests for related substances and residual solvents. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and cGMP-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 15.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.