Description

Methyl 6-(Trifluoromethyl)Pyrazine-2-Carboxylate is a high-value trifluoromethylated pyrazine derivative, a key building block in advanced organic synthesis. Its structure is prized for introducing the metabolically stable trifluoromethyl group and the versatile methyl ester functionality into target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to optimize the potency and physicochemical properties of new active ingredients.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Serves as a key precursor in the design and synthesis of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioactivity and environmental stability.
• Ligand & Catalyst Development: Used in the preparation of specialized pyrazine-based ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed as a monomer or functionalizing agent in the synthesis of advanced polymers and electronic materials.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	Methyl 6-(Trifluoromethyl)Pyrazine-2-Carboxylate
CAS No.	1644548-81-1
Molecular Formula	C7H5F3N2O2
Molecular Weight	206.12 g/mol
Synonyms	Methyl 6-(trifluoromethyl)pyrazine-2-carboxylate; 6-(Trifluoromethyl)pyrazine-2-carboxylic acid methyl ester; Methyl 6-(trifluoromethyl)-2-pyrazinecarboxylate; 2-Pyrazinecarboxylic acid, 6-(trifluoromethyl)-, methyl ester; Methyl 6-trifluoromethylpyrazine-2-carboxylate
EINECS	Contact for details

Quality Control

Every batch of Methyl 6-(Trifluoromethyl)Pyrazine-2-Carboxylate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles by HPLC, NMR, and GC-MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.