Description

tert-Butyl (6R)-6-Methyl-4H,5H,6H,7H-Pyrazolo[1,5-A]Pyrazine-5-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex bioactive molecules, offering a defined stereocenter and a protected carboxylate functional group for further derivatization. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in medicinal chemistry and process research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Process Chemistry: Serves as a critical starting material or intermediate in the scale-up and optimization of synthetic routes for candidate drugs.
• Asymmetric Synthesis: Employed in the construction of complex, enantiomerically pure molecules due to its defined (6R) stereochemistry.
• Proteolysis Targeting Chimera (PROTAC) & Bifunctional Molecules: A potential component in the synthesis of linker-payload systems for targeted protein degradation.
• Chemical Biology: Can be used as a tool compound or a precursor for labeled probes in biochemical and cellular studies.

Basic Information

Product Name	tert-Butyl (6R)-6-Methyl-4H,5H,6H,7H-Pyrazolo[1,5-A]Pyrazine-5-Carboxylate
CAS No.	1639881-13-2
Molecular Formula	C12H19N3O2
Molecular Weight	237.30 g/mol
Synonyms	(6R)-6-Methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-5-carboxylic acid tert-butyl ester; tert-Butyl (6R)-6-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-5-carboxylate; (R)-tert-Butyl 6-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-5-carboxylate; (6R)-6-Methyl-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazine-5-carboxylic acid, 1,1-dimethylethyl ester; 1639881-13-2; (R)-6-Methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-5-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (6R)-6-Methyl-4H,5H,6H,7H-Pyrazolo[1,5-A]Pyrazine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) documenting identity, purity (HPLC), chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.