Description

(R)-3-(Difluoromethoxy)Piperidine Hydrochloride is a high-purity, chiral piperidine derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process chemistry for creating enantiomerically pure therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the construction of complex molecular architectures for potential neurological and psychiatric treatments.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective chemical transformations.
• Process Development & Scale-up: Serves as a starting material for optimizing commercial-scale manufacturing routes for target molecules.

Basic Information

Product Name	(R)-3-(Difluoromethoxy)Piperidine Hydrochloride
CAS No.	1638744-82-7
Molecular Formula	C7H14ClF2NO
Molecular Weight	209.64 g/mol
Synonyms	(R)-3-(Difluoromethoxy)piperidine HCl; (R)-3-(Difluoromethoxy)piperidine hydrochloride; (3R)-3-(Difluoromethoxy)piperidine hydrochloride; Piperidine, 3-(difluoromethoxy)-, hydrochloride, (3R)-; (R)-3-(Difluoromethoxyl)piperidine hydrochloride; (R)-3-Difluoromethoxypiperidine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-3-(Difluoromethoxy)Piperidine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.