Description

(R)-tert-Butyl ((5,5-Difluoropiperidin-2-Yl)Methyl)Carbamate is a high-purity, chiral piperidine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and other bioactive molecules. Pharmaceutical researchers and fine chemical manufacturers need this intermediate for its precise stereochemistry and functional group compatibility, enabling the creation of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring a stereochemically defined, fluorinated piperidine scaffold.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization to introduce specific pharmacophores and modulate drug-like properties.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in catalytic asymmetric transformations to access enantiomerically pure compounds.
• Agrochemical Research: Potential application in the synthesis of novel, fluorinated agrochemicals where the difluoropiperidine moiety can influence biological activity and stability.
• Ligand and Catalyst Development: Can be utilized to construct novel chiral ligands or organocatalysts for use in enantioselective reactions.

Basic Information

Product Name	(R)-tert-Butyl ((5,5-Difluoropiperidin-2-Yl)Methyl)Carbamate
CAS No.	1638744-23-6
Molecular Formula	C12H22F2N2O2
Molecular Weight	264.31 g/mol
Synonyms	Carbamic acid, N-[(2R)-5,5-difluoro-2-piperidinyl]methyl-, 1,1-dimethylethyl ester; tert-Butyl N-[[(2R)-5,5-difluoropiperidin-2-yl]methyl]carbamate; (R)-tert-Butyl (5,5-difluoropiperidin-2-ylmethyl)carbamate; (R)-Boc-5,5-difluoropiperidin-2-ylmethylamine; (R)-N-Boc-5,5-difluoropiperidin-2-ylmethylamine; (R)-2-((tert-Butoxycarbonylamino)methyl)-5,5-difluoropiperidine; (R)-5,5-Difluoro-2-((((tert-butoxy)carbonyl)amino)methyl)piperidine
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl ((5,5-Difluoropiperidin-2-Yl)Methyl)Carbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical development. Products undergo rigorous analytical testing, including chiral HPLC to confirm enantiomeric purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.