Description

(S)-Alogliptin Benzoate Salt is a high-purity, enantiomerically pure active pharmaceutical ingredient (API) and key intermediate. This compound is a potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, making it a critical component in the development of advanced therapeutics for type 2 diabetes. It is essential for pharmaceutical R&D, process development, and the commercial manufacturing of innovative antidiabetic medications.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical substance in the synthesis of antidiabetic drugs.
• DPP-4 Inhibitor Development: Key intermediate in the research and development of novel dipeptidyl peptidase-4 inhibitors.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions.
• Process Chemistry & Scale-up: Used in process optimization, route scouting, and pilot-scale manufacturing for pharmaceutical production.
• Metabolic Disorder Research: A vital tool in preclinical and clinical studies targeting glucose metabolism and diabetes management.
• Formulation Development: Employed in the development of final dosage forms such as tablets and capsules.

Basic Information

Product Name	(S)-Alogliptin Benzoate Salt
CAS No.	1638544-64-5
Molecular Formula	C25H27N5O4
Molecular Weight	461.52 g/mol
Synonyms	Alogliptin Benzoate (S)-Isomer; (S)-2-({6-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile Benzoate; SYR-322 Benzoate Salt; Nesina® API Intermediate; (S)-Alogliptin Monobenzoate; 1-[[(S)-2-Cyanobenzyl]amino]acetyl-3-methyl-6-[(3R)-3-amino-1-piperidinyl]-2,4(1H,3H)-pyrimidinedione Benzoate
EINECS	Contact for details

Quality Control

Our (S)-Alogliptin Benzoate Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, suitable for pharmaceutical applications. A Certificate of Analysis (COA) detailing results for assay, enantiomeric purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.