Description

3-({[(tert-Butoxy)Carbonyl]Amino}Methyl)Cyclobutane-1-Carboxylic Acid is a high-purity, protected amino acid derivative featuring a cyclobutane backbone and a Boc-protected amine group. This compound is a critical building block in modern organic synthesis, enabling the controlled introduction of constrained, alicyclic structures into target molecules. It is primarily needed by pharmaceutical research and fine chemical synthesis teams for developing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting protease inhibitors, GPCR modulators, and other therapeutics requiring conformationally restricted scaffolds.
• Peptidomimetics Synthesis: Used to incorporate rigid, cyclobutane-based amino acid analogs into peptide chains to enhance metabolic stability, improve bioavailability, and explore novel structure-activity relationships (SAR).
• Chemical Biology Probes: Serves as a building block for creating labeled or tagged molecular probes to study enzyme function, protein-protein interactions, and other biological processes.
• Agrochemical Research: Employed in the synthesis of advanced intermediates for novel herbicides, fungicides, or plant growth regulators that benefit from sterically defined structures.
• Material Science: Potential monomer or cross-linking agent for synthesizing specialty polymers with unique thermal or mechanical properties derived from the cyclobutane ring.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns under cGMP or ISO standards.

Basic Information

Product Name	3-({[(tert-Butoxy)Carbonyl]Amino}Methyl)Cyclobutane-1-Carboxylic Acid
CAS No.	1630907-04-8
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	3-((Boc-amino)methyl)cyclobutane-1-carboxylic acid; 3-((((tert-Butoxy)carbonyl)amino)methyl)cyclobutane-1-carboxylic acid; 1-Cyclobutanecarboxylic acid, 3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-; 3-(Boc-aminomethyl)cyclobutanecarboxylic acid; 3-(N-Boc-aminomethyl)cyclobutanecarboxylic acid; Boc-3-(aminomethyl)cyclobutanecarboxylic acid; (3-((((tert-Butoxy)carbonyl)amino)methyl)cyclobutyl)carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 3-({[(tert-Butoxy)Carbonyl]Amino}Methyl)Cyclobutane-1-Carboxylic Acid adheres to stringent internal quality standards, ensuring batch-to-batch consistency and high purity suitable for research and development. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.