Description

(R)-tert-Butyl 2-Methyl-3-Oxopiperazine-1-Carboxylate is a high-purity chiral piperazinone derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules with high biological relevance. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of chiral drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of novel, stereoselective pesticides and herbicides.
• Asymmetric Synthesis: Serves as a chiral auxiliary or precursor in catalytic asymmetric reactions to introduce stereogenic centers.
• Peptidomimetics Development: Core structure for designing and synthesizing peptide analogs and protease inhibitors.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and process development.

Basic Information

Product Name	(R)-tert-Butyl 2-Methyl-3-Oxopiperazine-1-Carboxylate
CAS No.	1629229-82-8
Molecular Formula	C10H18N2O3
Molecular Weight	214.26 g/mol
Synonyms	1-Boc-3-oxo-2-methyl-(R)-piperazine; (R)-1-(tert-Butoxycarbonyl)-2-methylpiperazine-3-one; tert-Butyl (R)-2-methyl-3-oxopiperazine-1-carboxylate; (R)-2-Methyl-3-oxo-1-piperazinecarboxylic acid tert-butyl ester; (R)-1-N-Boc-2-methyl-3-oxopiperazine; (R)-Boc-2-methyl-3-oxopiperazine; (R)-tert-Butyl 2-methyl-3-oxo-1-piperazinecarboxylate; 1629229-82-8
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 2-Methyl-3-Oxopiperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.