Description

tert-Butyl (2R,3S)-3-Amino-2-Methylpiperidine-1-Carboxylate is a high-purity, stereochemically defined piperidine derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, protected amine scaffold essential for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, process development, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) and antiviral drugs.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce stereochemical complexity and modulate pharmacokinetic properties.
• Process Chemistry: Employed in the scalable synthesis of Active Pharmaceutical Ingredients (APIs) requiring a defined (2R,3S) stereochemistry.
• Agrochemical Research: Serves as a building block for developing new chiral pesticides and herbicides with enhanced efficacy and selectivity.
• Catalyst & Ligand Synthesis: A precursor for creating chiral catalysts and ligands used in asymmetric synthesis.
• Academic & Contract Research: Utilized in academic laboratories and CROs (Contract Research Organizations) for methodological development and exploratory synthesis.

Basic Information

Product Name	tert-Butyl (2R,3S)-3-Amino-2-Methylpiperidine-1-Carboxylate
CAS No.	1628258-94-5
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	1-Boc-3-amino-2-methylpiperidine (2R,3S)-isomer; (2R,3S)-1-(tert-Butoxycarbonyl)-3-amino-2-methylpiperidine; tert-Butyl (2R,3S)-3-amino-2-methyl-1-piperidinecarboxylate; (2R,3S)-3-Amino-2-methylpiperidine-1-carboxylic acid tert-butyl ester; (2R,3S)-3-Amino-2-methyl-1-N-Boc-piperidine; 1-N-Boc-(2R,3S)-3-amino-2-methylpiperidine; (2R,3S)-2-Methyl-3-aminopiperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (2R,3S)-3-Amino-2-Methylpiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and identity, to ensure compliance with exacting standards for research and development use. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.