Description

Carboxy-Peg4-Phosphonic Acid is a heterobifunctional polyethylene glycol (PEG) derivative featuring a carboxylic acid group and a phosphonic acid group, separated by a tetraethylene glycol spacer. This unique structure makes it a critical building block for creating stable, water-soluble conjugates and surface modifications, particularly in bioconjugation and materials science. It is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and nanotechnology sectors who require precise linker chemistry for attaching biomolecules to surfaces, nanoparticles, or other functional groups.

Application

• Bioconjugation Linker: Used to covalently attach peptides, proteins, or other biomolecules to surfaces, particles, or other molecules via its carboxylic acid and phosphonic acid termini.
• Surface Functionalization: The phosphonic acid group provides strong anchoring to metal oxide surfaces (e.g., titanium dioxide, iron oxide), making it ideal for creating biofunctional coatings on implants, diagnostic devices, and nanoparticles.
• Drug Delivery Systems: Serves as a versatile spacer/linker in the synthesis of targeted drug conjugates and advanced nanoparticle-based delivery platforms.
• Diagnostic Assay Development: Employed to immobilize capture antibodies or antigens on sensor surfaces for ELISA, lateral flow assays, and biosensors.
• Material Science: Used to modify the interface of inorganic materials to improve biocompatibility, reduce non-specific binding, or introduce specific chemical functionality.
• Click Chemistry & Crosslinking: The carboxylic acid group can be readily activated for amide bond formation or further derivatized to incorporate click chemistry handles (e.g., NHS ester, azide, alkyne).

Basic Information

Item	Detail
Product Name	Carboxy-Peg4-Phosphonic Acid
CAS No.	1623791-69-4
Molecular Formula	C11H23O10P
Molecular Weight	346.27 g/mol
Synonyms	4,7,10,13-Tetraoxa-16-azaheptadecane-1,17,17-triphosphonic acid (derivative); 17-Carboxy-4,7,10,13-tetraoxa-16-azaheptadecane-1,1-diphosphonic acid; Carboxy-PEG4-phosphonate; HOOC-PEG4-phosphonic acid; (17-Carboxy-4,7,10,13-tetraoxa-16-azaheptadecane-1,1-diyl)bisphosphonic acid; Amino-PEG4-acid-phosphonic acid derivative; Bifunctional PEG linker with carboxyl and phosphonate
EINECS	Contact for details

Quality Control

Our Carboxy-Peg4-Phosphonic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR (1H, 13C, 31P) for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Complies with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in water, DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.