Description

8-Boc-3,8-Diazabicyclo[3.2.1]Octan-2-One is a high-purity, protected bicyclic amine derivative, serving as a critical advanced pharmaceutical intermediate (API). Its value lies in providing a versatile, nitrogen-rich scaffold for constructing complex molecules in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates, especially in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry Scaffold: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained bicyclic structure.
• Agrochemical Synthesis: Serves as a precursor for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Ligand and Catalyst Development: Employed in the creation of chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	8-Boc-3,8-Diazabicyclo[3.2.1]Octan-2-One
CAS No.	1622919-66-7
Molecular Formula	C12H20N2O3
Molecular Weight	240.30 g/mol
Synonyms	tert-Butyl 2-oxo-3,8-diazabicyclo[3.2.1]octane-8-carboxylate; 8-(tert-Butoxycarbonyl)-3,8-diazabicyclo[3.2.1]octan-2-one; 3,8-Diazabicyclo[3.2.1]octan-2-one, 8-[(1,1-dimethylethoxy)carbonyl]-; BOC-DABCO Ketone; 8-Boc-3,8-diazabicyclo[3.2.1]octan-2-one; 8-Boc-2-oxo-3,8-diazabicyclo[3.2.1]octane
EINECS	Contact for details

Quality Control

Our 8-Boc-3,8-Diazabicyclo[3.2.1]Octan-2-One is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles. Our quality commitment aligns with ISO 9001 standards, and we can support development projects requiring ICH stability data or cGMP documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.