Description

1-(4-(5-(5-Amino-6-(5-(tert-Butyl)-1,3,4-Oxadiazol-2-Yl)Pyrazin-2-Yl)-1-Ethyl-1H-1,2,4-Triazol-3-Yl)Piperidin-1-Yl)-3-Hydroxypropan-1-One is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel small-molecule therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers targeting oncology, antiviral, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component for E3 ligase ligands or linkers due to its piperidine and triazole motifs.
• Kinase Inhibitor Synthesis: Employed in the development of targeted cancer therapies, leveraging its heterocyclic scaffold common in kinase binding domains.
• Bioconjugation & Chemical Biology: The amino and hydroxypropanone functional groups allow for further derivatization and conjugation in probe development.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Item	Details
Product Name	1-(4-(5-(5-Amino-6-(5-(tert-Butyl)-1,3,4-Oxadiazol-2-Yl)Pyrazin-2-Yl)-1-Ethyl-1H-1,2,4-Triazol-3-Yl)Piperidin-1-Yl)-3-Hydroxypropan-1-One
CAS No.	1620576-64-8
Molecular Formula	C22H31N9O3
Molecular Weight	469.54 g/mol
Synonyms	1-[4-[5-[5-Amino-6-[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]pyrazin-2-yl]-1-ethyl-1H-1,2,4-triazol-3-yl]piperidin-1-yl]-3-hydroxypropan-1-one; 1620576-64-8; UNII-9Q5V2J1Y1I; 3-Hydroxy-1-[4-[5-[5-amino-6-[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]-2-pyrazinyl]-1-ethyl-1H-1,2,4-triazol-3-yl]-1-piperidinyl]-1-propanone; 1-Propanone, 1-[4-[5-[5-amino-6-[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]-2-pyrazinyl]-1-ethyl-1H-1,2,4-triazol-3-yl]-1-piperidinyl]-3-hydroxy-
EINECS	Contact for details

Quality Control

Our 1-(4-(5-(5-Amino-6-(5-(tert-Butyl)-1,3,4-Oxadiazol-2-Yl)Pyrazin-2-Yl)-1-Ethyl-1H-1,2,4-Triazol-3-Yl)Piperidin-1-Yl)-3-Hydroxypropan-1-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.