Description

(S)-5-(6-Chloropyrazin-2-Yl)-2-(2-(Trifluoromethyl)Pyrrolidin-1-Yl)Pyrimidine is a high-value, chiral organic compound featuring a pyrimidine core linked to chloropyrazine and trifluoromethyl-substituted pyrrolidine moieties. This specific stereochemistry and functional group combination make it a critical advanced pharmaceutical intermediate (API) for the research and development of novel therapeutics. It is primarily sought after by pharmaceutical R&D organizations and fine chemical manufacturers engaged in drug discovery programs, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of potential active pharmaceutical ingredients (APIs) for clinical research.
• Drug Discovery & Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique trifluoromethyl and heterocyclic architecture.
• Kinase Inhibitor Development: The pyrimidine-pyrazine scaffold is commonly explored in the design of small molecule kinase inhibitors for targeted cancer therapies.
• CNS Drug Research: Applied in the development of compounds targeting neurological pathways, leveraging the physicochemical properties imparted by the trifluoromethyl group.
• Process Chemistry & Scale-Up: Used by CROs and CDMOs for route scouting, process optimization, and the production of non-GMP/ GMP batches for preclinical and clinical trials.
• Chemical Biology Probes: Utilized as a specialized reagent to study biological mechanisms and protein-ligand interactions in academic and industrial research settings.

Basic Information

Product Name	(S)-5-(6-Chloropyrazin-2-Yl)-2-(2-(Trifluoromethyl)Pyrrolidin-1-Yl)Pyrimidine
CAS No.	1620136-70-0
Molecular Formula	C13H10ClF3N6
Molecular Weight	342.71 g/mol
Synonyms	(S)-5-(6-Chloro-2-pyrazinyl)-2-[2-(trifluoromethyl)-1-pyrrolidinyl]pyrimidine; (S)-5-(6-Chloropyrazin-2-yl)-2-(2-(trifluoromethyl)pyrrolidin-1-yl)pyrimidine; 1620136-70-0; (S)-enantiomer of 5-(6-chloropyrazin-2-yl)-2-(2-(trifluoromethyl)pyrrolidin-1-yl)pyrimidine; UNII-8V6K5J0F5I; Pyrrolidine, 1-[5-(6-chloro-2-pyrazinyl)-2-pyrimidinyl]-2-(trifluoromethyl)-, (2S)-; 8V6K5J0F5I
EINECS	Contact for details

Quality Control

Every batch of (S)-5-(6-Chloropyrazin-2-Yl)-2-(2-(Trifluoromethyl)Pyrrolidin-1-Yl)Pyrimidine is manufactured and controlled under a strict quality management system. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high enantiomeric purity and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.