Description

3-((4-Methylpiperazin-1-Yl)Methyl)-5-(Trifluoromethyl)Benzoic Acid is a high-value, multi-functional organic building block featuring a benzoic acid core substituted with a trifluoromethyl group and a 4-methylpiperazinylmethyl moiety. This compound is critical for pharmaceutical research and development, serving as a key intermediate in the synthesis of targeted small molecule therapeutics. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecules with enhanced biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective drug discovery programs.
• Kinase Inhibitor Precursor: Used in the development of potent and selective kinase inhibitors, leveraging the piperazine and trifluoromethyl motifs for optimal target binding and metabolic stability.
• Agrochemical Synthesis: Serves as an advanced intermediate for creating novel herbicides and fungicides with improved efficacy and environmental profiles.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes for studying enzyme function and cellular signaling pathways.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique surface properties or optical characteristics.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales, from gram to kilogram.

Basic Information

Product Name	3-((4-Methylpiperazin-1-Yl)Methyl)-5-(Trifluoromethyl)Benzoic Acid
CAS No.	1616670-62-2
Molecular Formula	C14H17F3N2O2
Molecular Weight	302.29 g/mol
Synonyms	5-(Trifluoromethyl)-3-[(4-methyl-1-piperazinyl)methyl]benzoic Acid; 3-[(4-Methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)benzoic Acid; Benzoic acid, 3-((4-methyl-1-piperazinyl)methyl)-5-(trifluoromethyl)-; 1616670-62-2; 3-(4-Methylpiperazin-1-ylmethyl)-5-trifluoromethylbenzoic Acid; 3-((4-Methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)benzoic acid
EINECS	Contact for details

Quality Control

Our 3-((4-Methylpiperazin-1-Yl)Methyl)-5-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GLP (Good Laboratory Practice) and cGMP (current Good Manufacturing Practice) environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.