Description

tert-Butyl (2R,5S)-5-Hydroxy-2-Methylpiperidine-1-Carboxylate is a high-purity, stereochemically defined chiral piperidine derivative. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) and a versatile chiral building block for complex organic synthesis. It is essential for research and production in the pharmaceutical industry, particularly for developing active pharmaceutical ingredients (APIs) with specific stereochemical requirements.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of complex drug molecules, particularly those targeting the central nervous system (CNS) and infectious diseases.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and the discovery of new bioactive compounds.
• Peptidomimetics: Used in the design and synthesis of peptide analogs and conformationally restricted mimetics.
• Agrochemical Synthesis: Intermediate for developing chiral active ingredients in crop protection agents.
• Academic & Industrial R&D: Serves as a standard or starting material for methodological development in organic and medicinal chemistry laboratories.

Basic Information

Product Name	tert-Butyl (2R,5S)-5-Hydroxy-2-Methylpiperidine-1-Carboxylate
CAS No.	1616373-52-4
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	1-Boc-5-hydroxy-2-methylpiperidine (2R,5S)-isomer; (2R,5S)-1-(tert-Butoxycarbonyl)-5-hydroxy-2-methylpiperidine; tert-Butyl (2R,5S)-5-hydroxy-2-methyl-1-piperidinecarboxylate; (2R,5S)-5-Hydroxy-2-methylpiperidine-1-carboxylic acid tert-butyl ester; Boc-5-hydroxy-2-methylpiperidine (2R,5S); (2R,5S)-2-Methyl-5-hydroxypiperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (2R,5S)-5-Hydroxy-2-Methylpiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, enantiomeric excess (e.e.), and consistent performance. Certificates of Analysis (COA) detailing identity, purity (HPLC/GC), chiral purity, and residual solvent levels are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.