Description

Tos-Peg13-T-Butyl Ester CAS NO 1611497-11-0 is a specialized bifunctional PEG derivative featuring a tosylate (Tos) leaving group and a tert-butyl ester protecting group, connected by a 13-unit polyethylene glycol (PEG) spacer. This compound is engineered for high-value applications in bioconjugation and pharmaceutical development, offering controlled reactivity and enhanced solubility. It serves as a critical intermediate for researchers and manufacturers in the fields of advanced drug delivery systems, proteomics, and the synthesis of complex biomolecules.

Application

• Bioconjugation Linker: Acts as a heterobifunctional crosslinker for attaching drugs, dyes, or targeting ligands to proteins, antibodies, or nanoparticles.
• Pharmaceutical Intermediate: Used in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• PEGylation Reagent: Enables the site-specific modification of peptides and proteins to improve pharmacokinetic properties such as solubility and circulation half-life.
• Polymer Chemistry: Serves as a macroinitiator or building block for synthesizing functionalized, biocompatible polymers and hydrogels.
• Diagnostic Probe Synthesis: Facilitates the creation of contrast agents and fluorescent probes for imaging and diagnostic assays.
• Material Science: Used to modify surface properties of materials to enhance biocompatibility and reduce non-specific binding.

Basic Information

Product Name	Tos-Peg13-T-Butyl Ester
CAS No.	1611497-11-0
Molecular Formula	C36H74O17S
Molecular Weight	810.99 g/mol
Synonyms	1,1-Dimethylethyl 2,5,8,11,14,17,20,23,26,29,32,35,38-tridecaoxa-41-azatetracontan-41-oate 40-[(4-methylphenyl)sulfonyl]; tert-Butyl-PEG13-tosylate; tert-Butyl-PEG13-OTs; α-tert-Butyl ester-ω-tosyl-PEG13; Tos-PEG13-tBu ester; 4-Methylbenzenesulfonic acid PEG13 tert-butyl ester; Poly(ethylene glycol) derivative, tosyl-PEG13-t-butyl ester; Heterobifunctional PEG 13, t-butyl ester/Tosylate
EINECS	Contact for details

Quality Control

Every batch of Tos-Peg13-T-Butyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, impurity profile, and functional group integrity. Our quality commitment supports applications in GMP and research environments where reliable specifications are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Functional Group Analysis	Tosylation & t-Bu ester content confirmed
Average Molecular Weight (GPC)	810.99 ± 20 g/mol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.