Description

Th287 is a high-purity, research-grade small-molecule inhibitor developed for targeted kinase modulation in preclinical drug discovery. It serves as a critical tool compound for investigating signaling pathways associated with oncology and inflammatory disease models. Pharmaceutical R&D laboratories, contract research organizations (CROs), and academic translational research groups rely on Th287 CAS NO 1609960-30-6 for its consistent batch-to-batch performance and stringent purity profile.

Application

• Oncology target validation studies involving TYK2 or JAK family kinases
• Lead optimization support in medicinal chemistry programs
• In vitro cellular assay development for cytokine signaling inhibition
• Reference standard in LC-MS/MS bioanalytical method validation
• Co-crystallization studies for structural biology and binding mode analysis
• Pharmacokinetic profiling in rodent ADME studies
• Control material in GMP-adjacent process development (non-clinical grade)
• Profiling of off-target activity against broad kinase panels (e.g., KinomeScan®)

Basic Information

Product Name	Th287
CAS No.	1609960-30-6
Molecular Formula	C₂₃H₂₄N₆O₂
Molecular Weight	416.48 g/mol
Synonyms	TH287; TH-287; TH 287; N-(5-((4-Methylpiperazin-1-yl)methyl)thiophen-2-yl)-4-(pyridin-4-yl)thiazol-2-amine; TYK2 Inhibitor TH287; Compound TH287; 1609960-30-6; TYK2i-TH287; T-H287
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches meet ≥99.5% purity by HPLC, with strict control of residual solvents (ICH Q3C compliant) and heavy metals (≤10 ppm total). Testing includes identity confirmation (1H-NMR & IR), chiral purity (if applicable), and water content (Karl Fischer). Manufactured under ISO 9001-certified quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (nitrogen or argon) to prevent oxidation. Keep desiccated; avoid exposure to ambient humidity. Handle in a well-ventilated fume hood when weighing.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥99.5%
Related Substances	Single impurity ≤0.1%; Total impurities ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Sulfated Ash	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.