Description

(5R)-5-Methyl-2-Piperazinone Hydrochloride is a high-purity chiral piperazinone derivative, a crucial building block in modern pharmaceutical synthesis. This compound matters because it provides a stereochemically defined scaffold essential for developing active pharmaceutical ingredients (APIs) with targeted biological activity. Pharmaceutical R&D and process chemistry teams need it for the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and antiviral research domains.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the construction of complex molecular architectures for potential CNS therapies.
• Process Chemistry & Scale-Up: Serves as a critical starting material or intermediate in route development and optimization for commercial API manufacturing.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a defined stereocenter within a piperazinone ring system.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Employed in the study of enzyme inhibitors or receptor ligands due to its heterocyclic structure.

Basic Information

Product Name	(5R)-5-Methyl-2-Piperazinone Hydrochloride
CAS No.	1609388-52-4
Molecular Formula	C5H11N2O·HCl
Molecular Weight	150.62 g/mol (Free base: 114.16)
Synonyms	(R)-5-Methyl-2-piperazinone hydrochloride; (5R)-5-Methylpiperazin-2-one hydrochloride; (R)-5-Methylpiperazin-2-one HCl; 5-Methyl-2-piperazinone, (5R)-, hydrochloride; 2-Piperazinone, 5-methyl-, (5R)-, hydrochloride; (R)-5-Methyl-3,4,5,6-tetrahydropyrazin-2(1H)-one hydrochloride
EINECS	Contact for details

Quality Control

Our (5R)-5-Methyl-2-Piperazinone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.