Description

(R)-3-Phenyl-2-(Pyrazine-2-Carboxamido)Propanoic Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and a pyrazine heterocycle. This compound serves as a critical chiral building block and intermediate in advanced pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in areas targeting metabolic and central nervous system disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, especially peptidomimetics and enzyme inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its rigid pyrazine moiety and defined stereochemistry.
• Peptide & Protein Modification: Acts as a modified amino acid residue for the synthesis of non-natural peptides to enhance stability, bioavailability, or binding affinity.
• Chemical Biology Probes: Employed in the design and synthesis of chemical probes for studying biological pathways and target engagement.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective synthesis for creating complex molecular architectures.
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical manufacturing.

Basic Information

Product Name	(R)-3-Phenyl-2-(Pyrazine-2-Carboxamido)Propanoic Acid
CAS No.	1608986-16-8
Molecular Formula	C14H13N3O3
Molecular Weight	271.27 g/mol
Synonyms	(R)-2-(Pyrazine-2-carboxamido)-3-phenylpropanoic acid; D-2-(Pyrazine-2-carboxamido)-3-phenylpropionic acid; (R)-3-Phenyl-2-(pyrazine-2-ylcarboxamido)propanoic acid; (2R)-2-(Pyrazine-2-carbonylamino)-3-phenylpropanoic acid; (R)-N-(Pyrazin-2-ylcarbonyl)phenylalanine; (R)-Pyrazine-2-carboxylic acid (2-carboxy-1-phenylethyl)amide; (R)-α-(Pyrazine-2-carboxamido)benzenepropanoic acid
EINECS	Contact for details

Quality Control

Our (R)-3-Phenyl-2-(Pyrazine-2-Carboxamido)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.