Description

(R)-3-Methyl-5-(Piperidin-2-Yl)-1,2,4-Oxadiazole Hydrochloride is a high-purity, chiral organic salt of significant interest in advanced pharmaceutical research and development. This compound serves as a critical pharmacologically active intermediate or building block for the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams and contract research organizations (CROs) focused on central nervous system (CNS) targets, metabolic disorders, and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates targeting G-protein coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Preclinical Development: Serves as a reference standard or starting material for producing batches required for pharmacological and toxicological evaluation.
• Chemical Biology Probes: Utilized in the development of selective molecular probes for studying biological pathways and target validation.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective synthesis protocols.
• Contract Manufacturing: Supplied to CDMOs for the cGMP production of active pharmaceutical ingredients (APIs) in clinical trial stages.

Basic Information

Product Name	(R)-3-Methyl-5-(Piperidin-2-Yl)-1,2,4-Oxadiazole Hydrochloride
CAS No.	1604285-69-9
Molecular Formula	C8H14N3O·HCl
Molecular Weight	213.68 g/mol
Synonyms	(R)-3-Methyl-5-(2-piperidyl)-1,2,4-oxadiazole hydrochloride; (R)-5-(Piperidin-2-yl)-3-methyl-1,2,4-oxadiazole HCl; (2R)-3-Methyl-5-(2-piperidinyl)-1,2,4-oxadiazole hydrochloride; 1,2,4-Oxadiazole, 3-methyl-5-(2-piperidinyl)-, (2R)-, hydrochloride; UNII-6Q6E0IY4L2; 6Q6E0IY4L2; (R)-5-(2-Piperidyl)-3-methyl-1,2,4-oxadiazole hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-3-Methyl-5-(Piperidin-2-Yl)-1,2,4-Oxadiazole Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with full traceability are provided, confirming compliance with agreed specifications. We support development with custom purity grades and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.