Description

4-Chloro-2-Cyclopropylpyrazolo[1,5-A]Pyrazine CAS NO 1602060-23-0 is a high-purity, advanced pharmaceutical intermediate characterized by its fused pyrazolo[1,5-a]pyrazine heterocyclic core. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of small-molecule therapeutics, particularly for oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) for investigational new drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic targets.
• Kinase Inhibitor Development: Serves as a core scaffold for designing potent and selective kinase inhibitors due to the pyrazolo[1,5-a]pyrazine moiety's ability to mimic purine bases.
• Chemical Library Synthesis: Employed in combinatorial chemistry to generate diverse compound libraries for high-throughput screening (HTS).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development pipelines.
• Academic Research: Used in universities and research institutes for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	4-Chloro-2-Cyclopropylpyrazolo[1,5-A]Pyrazine
CAS No.	1602060-23-0
Molecular Formula	C9H8ClN3
Molecular Weight	193.63 g/mol
Synonyms	4-Chloro-2-cyclopropylpyrazolo[1,5-a]pyrazine; 2-Cyclopropyl-4-chloropyrazolo[1,5-a]pyrazine; 4-Chloro-2-cyclopropyl-[1,2,4]triazolo[1,5-a]pyrazine (common misnomer); 4-Chloro-2-cyclopropylpyrazolopyrazine; 1602060-23-0; Pyrazolo[1,5-a]pyrazine, 4-chloro-2-cyclopropyl-; 4-Chloro-2-cyclopropyl-1H-pyrazolo[1,5-a]pyrazine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Cyclopropylpyrazolo[1,5-A]Pyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with the standards required for GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.