Description

tert-Butyl (S)-3-(Cyanomethyl)Piperazine-1-Carboxylate is a high-purity, chiral piperazine derivative, serving as a critical building block in modern organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules with defined stereochemistry, essential for developing active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly in areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially protease inhibitors, kinase inhibitors, and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where the specific stereochemistry can influence biological activity.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of molecular probes and activity-based protein profiling (ABPP) reagents.
• Peptidomimetics: Integral for constructing non-peptide scaffolds that mimic peptide structures, enhancing metabolic stability for therapeutic applications.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric hydrogenation and other catalytic transformations.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity chiral intermediates.

Basic Information

Product Name	tert-Butyl (S)-3-(Cyanomethyl)Piperazine-1-Carboxylate
CAS No.	1589082-06-3
Molecular Formula	C11H19N3O2
Molecular Weight	225.29 g/mol
Synonyms	1-Boc-3-(cyanomethyl)-(S)-piperazine; (S)-1-tert-Butyl 2-(cyanomethyl)piperazine-1,2-dicarboxylate; (S)-tert-Butyl 3-(cyanomethyl)piperazine-1-carboxylate; (S)-N-Boc-3-(cyanomethyl)piperazine; (3S)-1-(tert-Butoxycarbonyl)-3-(cyanomethyl)piperazine; tert-Butyl (3S)-3-(cyanomethyl)piperazine-1-carboxylate; 1589082-06-3; (S)-1-Boc-3-(cyanomethyl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl (S)-3-(Cyanomethyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), chiral excess (>98% ee), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.