Description

3,5-Diethynylpyrazin-2-Amine is a high-purity, multi-functional organic building block characterized by its pyrazine core and terminal alkyne groups. This compound is of significant value in advanced materials science and pharmaceutical research due to its ability to participate in click chemistry reactions, such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and specialty polymer industries for the synthesis of complex molecular architectures, including conjugated polymers and bioactive heterocycles.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides with enhanced activity and selectivity.
• Material Science Building Block: Essential for creating conjugated polymers and organic semiconductors for use in OLEDs, solar cells, and sensors.
• Click Chemistry Reagent: The terminal ethynyl groups make it an ideal partner for Huisgen cycloaddition reactions to create triazole-linked bioconjugates and dendrimers.
• Ligand Synthesis: Employed in the preparation of novel nitrogen-containing ligands for catalysis and metal-organic frameworks (MOFs).
• Research & Development: A valuable tool for academic and industrial R&D in exploring new heterocyclic chemistry and structure-activity relationships (SAR).

Basic Information

Product Name	3,5-Diethynylpyrazin-2-Amine
CAS No.	1588440-99-6
Molecular Formula	C8H5N3
Molecular Weight	143.15 g/mol
Synonyms	2-Amino-3,5-diethynylpyrazine; 3,5-Diethynyl-2-pyrazinamine; 2-Pyrazinamine, 3,5-diethynyl-; 1588440-99-6; 3,5-Diethynylpyrazin-2-ylamine; 2-Amino-3,5-diethynylpyrazine; 3,5-Bis(ethynyl)pyrazin-2-amine
EINECS	Contact for details

Quality Control

Our 3,5-Diethynylpyrazin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.