Description

4-tert-Butyl-n-(Piperidin-3-Ylmethyl)-Benzamide Hydrochloride is a high-purity, non-racemic chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its complex molecular architecture, which incorporates a benzamide core linked to a substituted piperidine moiety, making it a versatile scaffold for medicinal chemistry and drug discovery programs. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly for central nervous system (CNS) and metabolic disorders.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of potential drug candidates targeting specific receptors.
• Medicinal Chemistry Research: Used as a key building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Chemical Biology Probes: Employed in the development of tool compounds for studying biological pathways and protein functions.
• Custom Synthesis: A starting material for the contract manufacturing of complex, high-value specialty chemicals and Active Pharmaceutical Ingredients (APIs).
• Library Synthesis: Utilized in combinatorial chemistry to create diverse compound libraries for high-throughput screening.

Basic Information

Product Name	4-tert-Butyl-n-(Piperidin-3-Ylmethyl)-Benzamide Hydrochloride
CAS No.	1582575-26-5
Molecular Formula	C18H29ClN2O
Molecular Weight	324.89 g/mol
Synonyms	4-tert-Butyl-N-[(3R)-piperidin-3-ylmethyl]benzamide hydrochloride; 4-tert-Butyl-N-(piperidin-3-ylmethyl)benzamide HCl; 4-tert-Butyl-N-(3-piperidinylmethyl)benzamide hydrochloride; Benzamide, 4-(1,1-dimethylethyl)-N-[(3R)-3-piperidinylmethyl]-, hydrochloride; (R)-4-tert-Butyl-N-(piperidin-3-ylmethyl)benzamide hydrochloride; 1582575-26-5; UNII-8K3F1Q8Q8H
EINECS	Contact for details

Quality Control

Our 4-tert-Butyl-n-(Piperidin-3-Ylmethyl)-Benzamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.