Description

tert-Butyl 2,6-Dimethylpiperazine-1-Carboxylate, Cis is a high-purity, cis-configured piperazine derivative protected by a tert-butoxycarbonyl (Boc) group. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate, enabling the synthesis of complex molecules with precise stereochemistry. It is essential for research and development in medicinal chemistry, particularly for the creation of active pharmaceutical ingredients (APIs) and fine chemicals requiring high stereochemical purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• API Synthesis: Used as a building block for constructing the core piperazine scaffolds found in numerous active pharmaceutical ingredients.
• Asymmetric Catalysis & Ligand Synthesis: Serves as a precursor for chiral ligands and catalysts used in enantioselective synthesis.
• Peptidomimetics & Bioactive Molecule Development: Integral for designing and synthesizing peptide analogs and other bioactive compounds with improved metabolic stability.
• Agrochemical Research: Employed in the development of novel, high-performance crop protection agents with specific stereochemical requirements.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new synthetic pathways in organic and medicinal chemistry laboratories.

Basic Information

Product Name	tert-Butyl 2,6-Dimethylpiperazine-1-Carboxylate, Cis
CAS No.	1575591-48-8
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	1-Boc-cis-2,6-dimethylpiperazine; (cis)-1-(tert-Butoxycarbonyl)-2,6-dimethylpiperazine; cis-2,6-Dimethylpiperazine-1-carboxylic acid tert-butyl ester; tert-Butyl cis-2,6-dimethylpiperazine-1-carboxylate; (2R,6S)-rel-2,6-Dimethylpiperazine-1-carboxylic acid tert-butyl ester; (2S,6R)-rel-2,6-Dimethylpiperazine-1-carboxylic acid tert-butyl ester; 1-N-Boc-cis-2,6-dimethylpiperazine; Boc-cis-2,6-dimethylpiperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,6-Dimethylpiperazine-1-Carboxylate, Cis is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% cis-isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.