Description

2-Cyclopropyl-2-Fluoroacetic Acid is a specialized fluorinated carboxylic acid building block of significant interest in advanced organic synthesis. Its unique structure, featuring a cyclopropyl ring adjacent to a fluorinated acetic acid moiety, makes it a valuable precursor for introducing sterically constrained, fluorine-containing motifs into target molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, where the cyclopropyl and fluorine groups can dramatically influence a compound's metabolic stability, lipophilicity, and biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, antivirals, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, where the fluorocyclopropyl group can enhance bioactivity and environmental persistence.
• Advanced Material Precursor: Serves as a building block for specialty polymers, liquid crystals, or organic electronic materials requiring specific fluorine-based properties.
• Fluorine Chemistry Research: An essential reagent in academic and industrial laboratories studying the effects of fluorination and cyclopropanation on molecular conformation and reactivity.
• Peptidomimetic & Bioisostere Development: Employed to create fluorinated cyclopropyl analogs of amino acids or other bioactive molecules to improve their pharmacokinetic profiles.

Basic Information

Product Name	2-Cyclopropyl-2-Fluoroacetic Acid
CAS No.	1554428-25-9
Molecular Formula	C5H7FO2
Molecular Weight	118.11 g/mol
Synonyms	2-Cyclopropyl-2-fluoroacetic acid; 2-Fluoro-2-cyclopropylacetic acid; Cyclopropanecarboxylic acid, fluoro-; Fluoro(cyclopropyl)acetic acid; (Cyclopropyl)fluoroacetic acid; α-Fluoro-α-cyclopropylacetic acid; 2-Fluoro-2-cyclopropylethanoic acid; 1554428-25-9
EINECS	Contact for details

Quality Control

Our 2-Cyclopropyl-2-Fluoroacetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.