Description

Benzyl (3R,4R)-3-Fluoro-4-Hydroxypiperidine-1-Carboxylate is a high-value, chiral piperidine derivative that serves as a critical synthetic intermediate in modern pharmaceutical development. This compound matters because its unique stereochemistry and functional groups make it an essential building block for constructing complex active pharmaceutical ingredients (APIs), particularly in the areas of neurology and oncology. Pharmaceutical R&D teams and advanced fine chemical manufacturers need this material to develop new therapeutic candidates with high enantiomeric purity and efficacy.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially for central nervous system (CNS) and anticancer therapeutics.
• Protease Inhibitor Precursor: Used in the research and development of protease inhibitors, leveraging the fluorinated hydroxypiperidine scaffold.
• Asymmetric Synthesis Building Block: Employed in stereoselective chemical reactions to introduce the (3R,4R)-3-fluoro-4-hydroxypiperidine moiety into target molecules.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Manufacturing: Integrated into Good Manufacturing Practice (GMP) production processes for final active pharmaceutical ingredients requiring this specific stereochemistry.
• Bioconjugation & Probe Development: Utilized in the development of biochemical probes and targeted conjugates for diagnostic and research applications.

Basic Information

Product Name	Benzyl (3R,4R)-3-Fluoro-4-Hydroxypiperidine-1-Carboxylate
CAS No.	1554141-63-7
Molecular Formula	C13H16FNO3
Molecular Weight	253.27 g/mol
Synonyms	1-Benzyloxycarbonyl-3-fluoro-4-hydroxypiperidine, (3R,4R)-; Benzyl 3-fluoro-4-hydroxypiperidine-1-carboxylate; (3R,4R)-1-(Benzyloxycarbonyl)-3-fluoro-4-hydroxypiperidine; 1-CBZ-3-fluoro-4-hydroxypiperidine (3R,4R)-; (3R,4R)-3-Fluoro-4-hydroxypiperidine-1-carboxylic acid benzyl ester; 3-Fluoro-4-hydroxypiperidine-1-carboxylic acid benzyl ester; Z-3-Fluoro-4-hydroxypiperidine; N-CBZ-(3R,4R)-3-fluoro-4-hydroxypiperidine
EINECS	Contact for details

Quality Control

Our Benzyl (3R,4R)-3-Fluoro-4-Hydroxypiperidine-1-Carboxylate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We adhere to relevant quality guidelines and our specifications are designed to meet the stringent requirements of cGMP production environments for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.