Description

Endo-8-Azabicyclo[3.2.1]Octane-3,8-Dicarboxylic Acid, 8-(1,1-Dimethylethyl) 3-Methyl Ester is a high-purity, advanced pharmaceutical intermediate with the CAS number 1548548-51-1. This bicyclic compound is valued for its rigid, three-dimensional scaffold, which is critical for imparting specific biological activity and metabolic stability in drug candidates. It is primarily sought by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules and novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Preclinical Drug Development: Serves as a critical raw material for producing compounds for pharmacological profiling, pharmacokinetic, and toxicology studies.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of target molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies in drug discovery and development pipelines.
• Academic Research: Utilized in university and institutional labs for synthetic organic chemistry and bioorganic research projects.

Basic Information

Product Name	Endo-8-Azabicyclo[3.2.1]Octane-3,8-Dicarboxylic Acid, 8-(1,1-Dimethylethyl) 3-Methyl Ester
CAS No.	1548548-51-1
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	8-tert-Butyl 3-methyl endo-8-azabicyclo[3.2.1]octane-3,8-dicarboxylate; 8-Azabicyclo[3.2.1]octane-3,8-dicarboxylic acid, 8-(1,1-dimethylethyl) 3-methyl ester, endo-; tert-Butyl 3-(methoxycarbonyl)-8-azabicyclo[3.2.1]octane-8-carboxylate; CAS 1548548-51-1; 8-Boc-3-methyl 8-azabicyclo[3.2.1]octane-3,8-dicarboxylate (endo); endo-3-(Methoxycarbonyl)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester; Azabicyclooctane dicarboxylate derivative.
EINECS	Contact for details

Quality Control

Our Endo-8-Azabicyclo[3.2.1]Octane-3,8-Dicarboxylic Acid, 8-(1,1-Dimethylethyl) 3-Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.