Description

1-(3-Chloro-Pyrazin-2-Yl)-Piperidine-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with the CAS number 1543014-69-2. This heterocyclic compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Serves as a crucial precursor in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Bioconjugation & Probe Development: The carboxylic acid functional group allows for further derivatization, making it useful for creating chemical probes and bioconjugates for biochemical assays.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production of investigational new drugs.

Basic Information

Product Name	1-(3-Chloro-Pyrazin-2-Yl)-Piperidine-4-Carboxylic Acid
CAS No.	1543014-69-2
Molecular Formula	C10H12ClN3O2
Molecular Weight	241.68 g/mol
Synonyms	4-Piperidinecarboxylic acid, 1-(3-chloro-2-pyrazinyl)-; 1-(3-Chloropyrazin-2-yl)piperidine-4-carboxylic acid; 1-(3-Chloro-2-pyrazinyl)-4-piperidinecarboxylic acid; 1543014-69-2; 3-Chloro-2-(4-carboxypiperidin-1-yl)pyrazine; Piperidine-4-carboxylic acid, 1-(3-chloro-2-pyrazinyl)-
EINECS	Contact for details

Quality Control

Our 1-(3-Chloro-Pyrazin-2-Yl)-Piperidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production can align with cGMP guidelines for advanced pharmaceutical intermediates to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.