Description

Bicyclo[1.1.1]pentane-1,3-dimethylamine dihydrochloride is a high-purity, functionalized bicyclic building block of significant interest in modern synthetic chemistry. This compound matters for its unique, highly strained [1.1.1]propellane core, which is prized for enabling three-dimensional structural complexity and serving as a bioisostere for phenyl rings and other aromatic systems in drug design. Pharmaceutical and agrochemical researchers need it for the development of novel active ingredients, particularly in fragment-based drug discovery and lead optimization programs where its rigid, three-dimensional geometry can improve potency and pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel small molecule therapeutics, especially in fragment-based drug discovery (FBDD).
• Bioisostere in Medicinal Chemistry: Used as a three-dimensional, sp3-rich replacement for flat aromatic rings (e.g., phenyl, para-substituted benzene) to modulate physicochemical properties like solubility and metabolic stability.
• Agrochemical Research: Employed in the synthesis of advanced crop protection agents and pesticides requiring unique steric profiles.
• Material Science Precursor: Serves as a specialized monomer or cross-linker for creating polymers with tailored mechanical properties.
• Chemical Biology Probes: Utilized in the development of molecular probes and tools for studying biological systems and target engagement.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis, particularly in strain-release chemistry and C–H functionalization.

Basic Information

Product Name	Bicyclo[1.1.1]pentane-1,3-dimethylamine Dihydrochloride
CAS No.	1523572-06-6
Molecular Formula	C9H18Cl2N2
Molecular Weight	225.16 g/mol
Synonyms	1,3-Bis(aminomethyl)bicyclo[1.1.1]pentane dihydrochloride; [1.1.1]Propellane-1,3-diyldimethanamine dihydrochloride; 1,3-Bis(aminomethyl)[1.1.1]propellane dihydrochloride; BCP-NH2·2HCl; Bicyclo[1.1.1]pentane-1,3-bis(methylamine) dihydrochloride; 1,3-Diaminomethylbicyclo[1.1.1]pentane dihydrochloride; 1,3-Bis(methylamino)bicyclo[1.1.1]pentane dihydrochloride (tautomer)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, impurities, and other critical parameters are available upon request. We adhere to strict internal quality management protocols to support our customers in pharmaceutical and advanced material research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.