Description

tert-Butyl 3,6-Diazabicyclo[3.2.1]octane-6-carboxylate hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a constrained diazabicyclic scaffold. This compound is critical for medicinal chemistry research and development, serving as a key building block for the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing central nervous system (CNS) drugs, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug candidates, particularly in neuroscience and oncology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its rigid, three-dimensional diazabicyclo[3.2.1]octane core.
• Protease Inhibitor Development: Serves as a precursor or core structure for designing novel protease inhibitors, including DPP-4 and other enzyme targets.
• Ligand Synthesis for Drug Discovery: Employed in creating sophisticated ligands for G-protein-coupled receptors (GPCRs) and other biological targets.
• Chemical Biology Probes: Utilized in the development of tool compounds and molecular probes for investigating biological pathways.
• Process Chemistry & Scale-Up: Sourced by CROs and CDMOs for process development and cGMP manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	tert-Butyl 3,6-Diazabicyclo[3.2.1]octane-6-carboxylate hydrochloride
CAS No.	1523571-18-7
Molecular Formula	C11H21ClN2O2
Molecular Weight	248.75 g/mol
Synonyms	6-Boc-3,6-diazabicyclo[3.2.1]octane hydrochloride; tert-Butyl 3,6-diazabicyclo[3.2.1]octane-6-carboxylate HCl; 3,6-Diazabicyclo[3.2.1]octane-6-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride; 6-(tert-Butoxycarbonyl)-3,6-diazabicyclo[3.2.1]octane hydrochloride; BOC-3,6-Diazabicyclo[3.2.1]octane HCl; 1523571-18-7; 3,6-Diazabicyclo[3.2.1]octane, 6-Boc-protected, hydrochloride salt
EINECS	Contact for details

Quality Control

Our tert-Butyl 3,6-Diazabicyclo[3.2.1]octane-6-carboxylate hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.