Description

(S)-Methyl-Piperazin-2-One Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its defined stereochemistry and salt form make it a critical component in the synthesis of targeted active pharmaceutical ingredients (APIs), particularly for neurological and psychiatric therapeutics. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders.
• API Synthesis: Used in the construction of piperazine-based pharmacophores for potential antidepressants, antipsychotics, and cognitive enhancers.
• Asymmetric Synthesis: Serves as a valuable starting material or reagent in stereoselective chemical transformations due to its (S)-configured stereocenter.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• Preclinical & Clinical Development: Supplied in development quantities for the production of non-GMP and GMP batches for toxicology studies and clinical trials.
• Contract Manufacturing: A reliable raw material for CDMOs producing bespoke compounds for their pharmaceutical clients.

Basic Information

Product Name	(S)-Methyl-Piperazin-2-One Hydrochloride
CAS No.	1523530-47-3
Molecular Formula	C5H11ClN2O
Molecular Weight	150.61 g/mol
Synonyms	(S)-1-Methylpiperazin-2-one hydrochloride; (S)-1-Methyl-2-piperazinone hydrochloride; (S)-N-Methyl-2-piperazinone hydrochloride; (S)-Methyl-2-oxopiperazine hydrochloride; (S)-1-Methyl-2-ketopiperazine HCl; (S)-1-Methylpiperazine-2-one HCl; (S)-MPO HCl; (2S)-1-Methyl-1,4-diazepan-2-one hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Methyl-Piperazin-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.