Description

Benzyl (3S,4S)-4-Amino-3-Fluoropiperidine-1-Carboxylate is a high-purity, fluorinated piperidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold with both amino and fluorine functionalities, enabling the development of novel compounds with enhanced biological activity and metabolic stability. This intermediate is essential for research and development chemists in the pharmaceutical industry, particularly those focused on creating new active pharmaceutical ingredients (APIs) for central nervous system (CNS) disorders, oncology, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting protease inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of advanced, fluorinated active ingredients for crop protection with potentially improved efficacy and environmental profile.
• Chemical Biology & Probe Development: Serves as a versatile scaffold for creating molecular probes to study enzyme function and biological pathways due to its fluorine atom and amine handle.
• Peptidomimetics: Incorporated into peptide analogs to enhance stability, bioavailability, and binding affinity by leveraging the fluoropiperidine structure.
• Ligand Synthesis for Catalysis: Utilized in the preparation of chiral ligands for asymmetric catalysis, contributing to more efficient and selective synthetic routes.

Basic Information

Product Name	Benzyl (3S,4S)-4-Amino-3-Fluoropiperidine-1-Carboxylate
CAS No.	1523530-09-7
Molecular Formula	C13H17FN2O2
Molecular Weight	252.29 g/mol
Synonyms	1-CBz-3-Fluoro-4-aminopiperidine (3S,4S)-Isomer; (3S,4S)-1-(Benzyloxycarbonyl)-3-fluoro-4-aminopiperidine; (3S,4S)-4-Amino-3-fluoro-1-piperidinecarboxylic acid benzyl ester; Benzyl N-[(3S,4S)-4-amino-3-fluoropiperidin-1-yl]formate; 4-Amino-3-fluoropiperidine-1-carboxylic acid benzyl ester (S,S)-isomer; 1523530-09-7; (3S,4S)-1-Cbz-4-amino-3-fluoropiperidine
EINECS	Contact for details

Quality Control

Our Benzyl (3S,4S)-4-Amino-3-Fluoropiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.