Description

1-Piperidinecarboxylic Acid, 4-Hydroxy-2,2-Dimethyl-, 1,1-Dimethylethyl Ester is a high-purity, protected amino acid derivative of significant interest in advanced organic synthesis. This compound serves as a critical building block for the development of novel pharmaceutical intermediates and fine chemicals, offering precise stereochemical control. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder drugs.
• Peptidomimetics Research: Used to incorporate constrained, hydroxylated piperidine motifs into peptide backbones to enhance stability and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and receptor interactions.
• Agrochemical Synthesis: Potential intermediate in the development of advanced, high-selectivity herbicides and fungicides.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific, multi-step synthetic projects.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 4-Hydroxy-2,2-Dimethyl-, 1,1-Dimethylethyl Ester
CAS No.	1502162-73-3
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	tert-Butyl 4-hydroxy-2,2-dimethylpiperidine-1-carboxylate; 4-Hydroxy-2,2-dimethylpiperidine-1-carboxylic acid tert-butyl ester; Boc-4-hydroxy-2,2-dimethylpiperidine; N-Boc-4-hydroxy-2,2-dimethylpiperidine; 1-(tert-Butoxycarbonyl)-4-hydroxy-2,2-dimethylpiperidine; 2,2-Dimethyl-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; (4-Hydroxy-2,2-dimethyl-1-piperidinyl)-1,1-dimethylethyl formate
EINECS	Contact for details

Quality Control

Our 1-Piperidinecarboxylic Acid, 4-Hydroxy-2,2-Dimethyl-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.