Description

(1R,5R,6S)-5-Hydroxy-7-Oxabicyclo[4.1.0]Hept-2-Ene-3-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and bicyclic oxabicycloheptene core structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutic agents where precise molecular geometry is essential for biological activity. It serves as a key building block for research and production in pharmaceutical, agrochemical, and fine chemical industries, enabling the creation of molecules with targeted properties.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates, especially in antiviral, antibacterial, and anti-inflammatory research pipelines.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where its unique bicyclic structure contributes to biological efficacy.
• Fine Chemical Production: Serves as a specialized building block for creating complex fragrance molecules, flavors, and other high-value specialty chemicals.
• Academic & R&D: Employed in organic chemistry research for methodology development, total synthesis projects, and studying stereoselective reactions.
• Material Science Precursor: Potential use in synthesizing monomers or ligands for advanced polymeric materials or metal-organic frameworks (MOFs).

Basic Information

Product Name	(1R,5R,6S)-5-Hydroxy-7-Oxabicyclo[4.1.0]Hept-2-Ene-3-Carboxylic Acid Ethyl Ester
CAS No.	1476028-68-8
Molecular Formula	C10H12O5
Molecular Weight	212.20 g/mol
Synonyms	Ethyl (1R,5R,6S)-5-hydroxy-7-oxabicyclo[4.1.0]hept-2-ene-3-carboxylate; 7-Oxabicyclo[4.1.0]hept-2-ene-3-carboxylic acid, 5-hydroxy-, ethyl ester, (1R,5R,6S)-; (1R,5R,6S)-5-Hydroxy-7-oxabicyclo[4.1.0]hept-2-ene-3-carboxylic acid ethyl ester; Bicyclic Oxabicycloheptene Ester; Chiral Oxabicycloheptene Derivative; Advanced Pharmaceutical Intermediate CAS 1476028-68-8
EINECS	Contact for details

Quality Control

Our (1R,5R,6S)-5-Hydroxy-7-Oxabicyclo[4.1.0]Hept-2-Ene-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We adhere to cGMP principles where applicable to ensure traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.