Description

1-(4-(2-((4-Chloro-2-Hydroxy-5-Iodophenyl)Amino)Acetyl)Piperazin-1-Yl)Prop-2-En-1-One is a sophisticated heterocyclic compound featuring a piperazine core functionalized with a chlorohydroxyiodoaniline moiety and an acryloyl group. This unique molecular architecture makes it a valuable pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small-molecule drugs, particularly those designed for kinase inhibition or other protein-protein interaction targets.
• Medicinal Chemistry Research: Serves as a crucial scaffold for constructing compound libraries in drug discovery programs to explore structure-activity relationships (SAR).
• Chemical Probe Development: Used in the development of selective chemical probes for studying biological pathways and target validation in cellular assays.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) during late-stage development.
• Bioconjugation: The reactive acryloyl group enables its use in bioconjugation chemistry for linking small molecules to proteins, antibodies, or other biomolecules.

Basic Information

Product Name	1-(4-(2-((4-Chloro-2-Hydroxy-5-Iodophenyl)Amino)Acetyl)Piperazin-1-Yl)Prop-2-En-1-One
CAS No.	1469337-95-8
Molecular Formula	C15H16ClIN3O3
Molecular Weight	448.66 g/mol
Synonyms	N-(4-Chloro-2-hydroxy-5-iodophenyl)-2-(4-acryloylpiperazin-1-yl)acetamide; 2-((4-Chloro-2-hydroxy-5-iodophenyl)amino)-1-(4-acryloylpiperazin-1-yl)ethanone; 1-(4-(2-((4-Chloro-2-hydroxy-5-iodophenyl)amino)acetyl)piperazin-1-yl)prop-2-en-1-one; Acrylamide derivative CAS 1469337-95-8; Chlorohydroxyiodoaniline-piperazine-acrylamide conjugate
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical intermediate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.