Description

[(3R)-1-[2-[1-(4-Chloro-1H-Pyrazol-1-Yl)Cyclopropyl]-3H-Imidazo[4,5-B]Pyridin-5-Yl]-3-Piperidinyl]-1-Pyrrolidinyl-Methanone Methanesulfonate is a high-purity, non-racemic chiral compound designed for advanced pharmaceutical research and development. This complex heterocyclic molecule serves as a critical pharmacologically active intermediate or reference standard in the discovery of new therapeutic agents. It is primarily utilized by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in medicinal chemistry and preclinical studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs.
• Reference Standard: Serves as an analytical standard for method development, validation, and quality control in API manufacturing.
• Biochemical Tool Compound: Employed in in-vitro and in-vivo assays to investigate biological mechanisms and target engagement.
• Preclinical Development: Supports early-stage development activities, including pharmacokinetic and toxicology studies.
• Custom Synthesis Starting Material: Provides a sophisticated chiral scaffold for the custom synthesis of proprietary analogs.

Basic Information

Product Name	[(3R)-1-[2-[1-(4-Chloro-1H-Pyrazol-1-Yl)Cyclopropyl]-3H-Imidazo[4,5-B]Pyridin-5-Yl]-3-Piperidinyl]-1-Pyrrolidinyl-Methanone Methanesulfonate
CAS No.	1469284-79-4
Molecular Formula	C24H28ClN7O · CH4O3S
Molecular Weight	Contact for details
Synonyms	(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate; UNII-8V8T6Q4F4P; 8V8T6Q4F4P; Methanesulfonic acid compound with (3R)-1-[2-[1-(4-chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone (1:1); (R)-1-(2-(1-(4-chloro-1H-pyrazol-1-yl)cyclopropyl)-3H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone methanesulfonate
EINECS	Contact for details

Quality Control

Our [(3R)-1-[2-[1-(4-Chloro-1H-Pyrazol-1-Yl)Cyclopropyl]-3H-Imidazo[4,5-B]Pyridin-5-Yl]-3-Piperidinyl]-1-Pyrrolidinyl-Methanone Methanesulfonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure identity, potency, and purity. Certificates of Analysis (COA) detailing specifications and test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.