Description

Sucralose-D6 is a stable isotope-labeled analog of the high-intensity artificial sweetener sucralose, specifically deuterated at six positions. This compound is an essential internal standard for the precise quantification and metabolic study of sucralose using advanced analytical techniques like LC-MS/MS. It is primarily required by analytical laboratories, research institutions, and pharmaceutical companies engaged in food safety testing, regulatory compliance, and pharmacokinetic research to ensure accurate and reliable data.

Application

• Internal Standard for Mass Spectrometry: Used as a deuterated internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the accurate quantification of sucralose in complex matrices.
• Food and Beverage Analysis: Critical for testing sucralose content and ensuring label claim verification in diet sodas, low-calorie foods, and other sweetened products.
• Pharmacokinetic and Metabolic Studies: Enables tracing and quantification of sucralose and its metabolites in biological fluids (plasma, urine) during ADME (Absorption, Distribution, Metabolism, Excretion) research.
• Environmental Monitoring: Applied in analytical methods to detect and measure trace levels of sucralose as an anthropogenic marker in water treatment studies and environmental samples.
• Method Development and Validation: Serves as a key reference material for developing, optimizing, and validating robust analytical methods in compliance with FDA, EPA, or other regulatory guidelines.
• Quality Control and Assurance: Employed in QC laboratories of ingredient suppliers and finished product manufacturers to ensure batch-to-batch consistency and purity of sucralose raw material.

Basic Information

Product Name	Sucralose-D6
CAS No.	1459161-55-7
Molecular Formula	C12H13D6Cl3O8
Molecular Weight	405.69 g/mol
Synonyms	1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside-d6; 4,1',6'-Trichloro-4,1',6'-trideoxygalactosucrose-d6; Deuterated Sucralose; Sucralose (hexadeuterated); Splenda-d6; E955-d6; INS 955-d6; TGS-d6
EINECS	Contact for details

Quality Control

Every batch of Sucralose-D6 is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing critical parameters such as isotopic purity, chemical purity, and absence of interferents. Our quality commitment ensures the material meets the stringent requirements for use as an internal standard in regulated analytical environments, supporting methods compliant with ISO 17025, FDA, and other global standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which could affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.